A variety of tissue-specific autoantibodies correlate with the time to development of APAH. Shown are Kaplan-Meier curves illustrating the correlation between the time to development of APAH with the presence or absence of autoantibodies against (A) AADC, (B) CYP1A2, (C) HDC, (D) BPIFB1, (E) TPH, and (F) 21-OH. P values were generated using the log-rank test for significance (n = 42). Abbreviations: APAH, APECED-associated hepatitis; KM, Kaplan-Meier; AADC, aromatic L-amino acid decarboxylase; BPIFB1, bactericidal/permeability-increasing fold-containing B1; CYP1A2, steroid 21-hydroylase; HDC, histidine decarboxylase; TPH, tryptophan hydroxylase; 21-OH, 21-hydroxylase.