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. 2022 Apr 22;119(18):e2110085119. doi: 10.1073/pnas.2110085119

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Copyright © 2022 the Author(s). Published by PNAS.

This article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND).

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Fig. 5. — Fully active state of 5-HT_2A-Gq protein. Comparison of Gαq in our optimized fully active 25CN-NBOH-5-HT_2A-Gq protein with (A) inactive Gαq protein-bound GDP and (B) fully active nucleotide free mini-Gαq subunit (54) resolved by cryo-EM. Comparison of the cytoplasmic region of 5-HT_2A in our optimized fully active 25CN-NBOH-5-HT_2A-Gq protein with (C) the inactive conformation (54) (Protein Data Bank [PDB]: 6WH4) resolved by X-ray crystallography and (D) the active conformation (54) (PDB: 6WHA) resolved by cryo-EM.