Figure 1.

Collaboration, competition and litigation related to LNP technology

CLA = cross-license agreement; DMSA = development, manufacturing, supply agreement.; LCA = license and collaboration agreement; Option agreement = an agreement that confers upon one or more parties the right to renew an existing agreement.

A number of the companies mentioned in this figure underwent corporate reorganizations during the time-frame depicted: Inex was reorganized as Tekmira and then later as Arbutus; Protiva was a subsidiary of Tekmira; and AlCana subsequently became Acuitas.

All of the information depicted in this figure was derived from publicly available information on the website of the US Securities and Exchange Commission (https://www.sec.gov/).