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. 2022 May 13;18(5):e1010161. doi: 10.1371/journal.pgen.1010161

Fig 2. ConjFDR Manhattan plot.

Fig 2

Common genetic variants both associated with depression (n = 450,619) and a) CAD (n = 502,713), b) SBP (n = 750,000) and c) LDL (n = 297,626) at conjunctional false discovery rate (conjFDR) < 0.05. Manhattan plot showing the–log10 transformed conjFDR values for each SNP on the y axis and the chromosomal positions along the x axis. The dotted horizontal line represents the threshold for significant shared associations (conjFDR < 0.01, i.e. -log10(conjFDR) > 2.0). Independent lead SNPs are encircled in black, and labeled by its nearest gene. The significant shared signal in the major histocompatility complex region (chr6:25119106–33854733) is represented by one independent lead SNP. Further details are available in S8 Table. Dep; depression, CAD; coronary artery disease, SBP; systolic blood pressure, LDL; low-density lipoprotein.