Table 1. Number if distinct genomic loci jointly associated with depression and CAD and CVD risk factors, the effect directions and the number of novel loci for depression.
CAD; coronary artery disease, T2D; type 2 diabetes, CRP; c-reactive protein, HDL; high-density lipoprotein, LDL; low-density lipoprotein, TC; total cholesterol, TG; triglycerides, DBP; diastolic blood pressure, SBP; systolic blood pressure.
| CAD/Cardiovascular associated trait | No of loci | Concordant effect (%) | Novel in depression | No of loci overlapping with condFDR DEP|CVD (%) | No of loci overlapping with condFDR CVD|DEP (%) |
|---|---|---|---|---|---|
| CAD | 6 | 83.33 | 1 | 4 (67) | 3 (50) |
| T2D | 9 | 22.22 | 3 | 4 (44) | 3 (33) |
| CRP | 8 | 75.00 | 4 | 3 (37.5) | 4 (50) |
| HDL | 14 | 28.57 | 5 | 6 (43) | 9 (64) |
| LDL | 10 | 55.6 | 1 | 9 (90%) | 5 (50) |
| TC | 11 | 45.45 | 2 | 9 (82) | 8 (73) |
| TG | 14 | 86.00 | 6 | 6 (43) | 13 (93) |
| DBP | 31 | 41.94 | 7 | 16 (52) | 18 (58) |
| SBP | 38 | 24.00 | 12 | 17 (45) | 26 (68) |