a, The number of samples with and without SGTF by day from 1 November 2020 to 14 February 2021, the period covered by our main analysis. b, Number of deaths within 28 days of a positive test by specimen date for all data included in the analysis. c, Kaplan–Meier plot showing survival (point estimates and 95% confidence intervals) among individuals tested in the community in England with and without SGTF, in the subset for whom SGTF was measured. The inset shows the full y-axis range. d–i, Crude death rates (point estimates and 95% confidence intervals) among SGTF versus non-SGTF cases (in the subset for whom SGTF was measured; n = 1,146,534) for deaths within 28 days of a positive test stratified by broad age groups and sex (d), residence type (e), ethnicity (f), IMD decile (g), region of NHS England (h) and specimen date (i). Horizontal bars show the overall crude death rates (point estimates and 95% confidence intervals) by age group irrespective of SGTF status.