Figure 3.

Maresin-1 mitigates AAA formation via smooth muscle cell-dependent TGF-β2 signaling. A, Schematic description of elastase AAA model in tamoxifen-treated SMC-Tgfβr2^−/− mice. B, MaR1 treated SMC-Tgfβr2^−/− mice showed no difference in aortic diameter compared to vehicle treated SMC-Tgfβr2^−/− mice or elastase-treated WT mice (n=9–11 mice per group; ns, not significant). C, Representative images of aortic phenotype in respective groups. D, Expression of smooth muscle cell-α actin is similar in SMC-Tgfβr2^−/− mice treated with MaR1 compared to mice treated with vehicle alone (n=4–5/group; ns, not significant). E, Representative histological images of smooth muscle-α actin staining in respective groups. Images were acquired using 20X magnification.