Table 2.

Summary of advantages and disadvantages of three models of acute lung injury induction.

Model	Advantage	Disadvantage
LPS	Good model of sepsis.	Lung injury does not mimic human ALI/ARDS (minimal intra-alveolar neutrophilic infiltrates and protein-rich alveolar edema).
Hyperoxia	Good model of hemorrhagic injury.	Less intra-alveolar neutrophilic infiltrates than in human ARDS.
Mesenteric ischemia reperfusion	Good models of sepsis.	Injury is localized primarily to the vascular and interstitial compartments of the lung.