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. 2022 Jun 3;219(7):e20220017. doi: 10.1084/jem.20220017

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© 2022 Li et al.

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Figure S5. — Testing innate adaptor molecules used by OV to stimulate Mmp12 expression and IR-ATM signature. (A) Mmp12 gene expression in RAW cells treated with HK OV (mean ± SD, n = 3, two-tailed, unpaired, parametric t test, ***P < 0.001). (B) Mmp12 meta-signature gene expression change in human diabetic subjects compared to healthy controls and in macrophage cell line treated with OV compared to vehicle (Fisher’s P value < 0.05 for human data and two-tailed parametric P < 0.05 for macrophage cells). (C) Mmp12 gene expression in RAW cells treated with OV and (top right) siRNAs Myd88 (n = 10). Top right: siRNAs Mavs, Ripk2 (mean ± SD, n = 3, two-tailed, unpaired, parametric t test, ***P < 0.001). Top left: Mmp12 gene expression in RAW cells treated with siRNAs Ticam-1. Bottom right: Ticam-1^−/− IMM cells (right; mean ± SD, n = 5 independent experiments, one-tailed, unpaired, parametric t test, ****P < 0.0001).