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. 2021 Mar 15;9(4):915–927. doi: 10.1016/j.gendis.2021.03.002

Figure 3.

Figure 3

Signal molecules regulating CaN activity to mediate podocyte injury. (1) AT1-AA induces podocyte injury via activation of the TRPC6- Ca2+/CaN pathway. (2) Ang II contributes to podocyte injury by increasing TRPC6 expression, which activates CaN/NFAT signaling. (3) Ang II induces Ca2+/CaN signaling and podocyte injury by downregulating miR-30 family members. (4) RANK promotes podocyte injury by activating Ca2+/CaN/NFAT signaling. (5) MiR-30 family members inhibit uPAR-ITGB3 signaling activation through the CaN/NFAT pathway.