Table 2.

Pharmacotherapy and Ancillary Treatment Options for GWS Symptoms

Medication / Modality	Examples	Signs / Symptoms Addressed
Antidepressants	Sertraline, fluoxetine, trazodone	Mood disturbance, anorexia, poor sleep
Nonsteroidal anti-inflammatory drugs	Celecoxib	Musculoskeletal discomfort
Bone-directed drugs	Alendronate, zoledronate, teriparatide, abaloparatide	Osteoporosis, fragility fractures
Physical therapy		Physical deconditioning, musculoskeletal discomfort
Cognitive therapy		Mood disturbance, disease coping