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. 2022 Jan 5;110(3):523–534. doi: 10.1007/s10266-021-00684-3

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — Immunohistochemical expression of OPN from treated dogs with MPM and PRF across all time intervals. a, b Photomicrographs showing changes in OPN immune-positivity at 4-weeks’ time point OPN with strong positive immune expression in the extracellular matrix in both MPM and PRF with no significant difference. c, d Decrease in OPN immune-staining is seen at 8-weeks in both MPM and PRF. e, f Further decrease in OPN staining is noted in both MPM and PRF treated groups at 12-weeks’ interval with linear deposition of OPN immunoreaction across the cement lines in MPM while, less homogeneously dispersed OPN immune positivity throughout the osteon was noted in the PRF group. g Photograph for the negative control group with reduced OPN immunoreaction seen only in the scanty bone marrow. h A representative graph showing the difference in mean area percentage of OPN immunoexpression between MPM and PRF across all study periods with a statistical significance at 8-weeks interval denote by an asterisk (P < 0.05). i A representative graph illustrating 12-weeks mean area percent for MPM, PRF and negative control groups showing almost the same results for all groups with no significant difference. (All sections are stained with OPN × 400)