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. 2022 Jun 6;13:3124. doi: 10.1038/s41467-022-30875-7

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Representation of genome-wide association studies (GWAS) of the lipidome in the BHS discovery cohort (blue boxes), ADNI and AIBL validation cohorts (green boxes), discovery meta-analysis (orange box), and downstream analyses (grey boxes). ADNI Alzheimer’s Disease Neuroimaging Initiative, AIBL Australian Imaging, Biomarker & Lifestyle Flagship Study of Ageing, BHS Busselton Health Study, CAD coronary artery disease, Chol cholesterol, eQTL expression quantitative trait loci, GRM genetic relatedness matrix, GWAS genome-wide association study, IVW inverse-variance weighted, LD linkage disequilibrium, MAC minor allele count, meQTL methylation quantitative trait loci, mQTL metabolite quantitative trait loci, PC principal component, PRS polygenic risk score, pQTL protein quantitative trait loci, SD standard deviation, SNP single nucleotide polymorphism, Trig triglycerides.