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. 2022 Jun 6;13:3127. doi: 10.1038/s41467-022-30898-0

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a, b Volcano plots showing differentially expressed genes in response to P4 in responders a and non-responders b, three different PDXs, each 3-4 biological replicates. All highlighted genes have p values <0.05 according to the limma model used for differential expression analysis. Genes with log2(FC) >0.5 in red and log2(FC) <0.5 in blue. Names of selected genes are indicated. c, d Dot plots showing differentially enriched hallmark gene sets upon P4 stimulation in tumors that respond with proliferation to P4 (responders) (c) versus tumors that do not (non-responders) (d), three different PDXs, each 3-4 biological replicates. e Dot plot showing differentially enriched hallmark gene sets in unstimulated tumors that respond with proliferation to P4 (responders) versus tumors that do not (non-responders).