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. 2022 Jun 6;13:3130. doi: 10.1038/s41467-022-30868-6

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a, b Changes of intracarotid arterial MAP under L1-L2 DRG injection with capsaicin post PRATA, n = 5 for WKY-Sham + Cap and WKY-PRATA-4wk + Cap groups, n = 10 for SHR-Sham + Cap group, n = 8 for SHR-PRATA-4wk + Cap group, n = 6 for SHR-PRATA-12wk + Cap group; Data are mean ± SEM. *P < 0.05. ANOVA, Bonferroni post-hoc test, two-sided. c, d Changes of the intracarotid arterial MAP after selective inhibition of neuronal activity of L1-L2 DRGs using Gi-DREADDs in SHR, n = 5 for Saline-DREADD and CNO-DREADD group, n = 6 for Saline-mCherry and CNO-mCherry group; Data are mean ± SEM. *P < 0.05, ***P < 0.001, ****P < 0.0001 compared with Saline-DREADD group. ANOVA, Bonferroni post-hoc test, two-sided. e Changes of the intracarotid arterial MAP post PRATA with or without T12 spinal cord mutilation, n = 6 for SHR-PRATA group, n = 5 for SHR-PRATA + T12 mutilation group; Data are mean ± SEM. ***P < 0.001, ****P < 0.0001. ANOVA, Bonferroni post-hoc test, two-sided. f Changes of the intracarotid arterial MAP post PRAT denervation by RTX in SHRs, n = 6 per group; Data are mean ± SEM. *P < 0.05, **P < 0.01. ANOVA, Bonferroni post-hoc test, two-sided. g Weekly measurement of tail arterial BP post three repeated PRATD by RTX in SHRs, n = 6 per group; Data are mean ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001. ANOVA, Bonferroni post-hoc test, two-sided. h, i Weekly measurement of tail arterial BP post PRATD in HFD induced hypertensive rats (h) and HSD induced hypertensive rats (i), n = 8 for HFD-HTN-Saline→PRAT group, n = 7 for HFD-HTN-RTX → PRAT group in (h); n = 7 per group in (i); Data are mean ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001. ANOVA, Bonferroni post-hoc test, two-sided. Saline→PRAT: injection of saline into perirenal adipose tissue, RTX → PRAT: injection of resiniferatoxin into perirenal adipose tissue.