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. 2022 Jun 6;13:3130. doi: 10.1038/s41467-022-30868-6

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a, b Differential gene expression in L1-L2 DRG neurons 4 weeks post PRATA. Hierarchical cluster and volcano analysis of 433 genes expressed differentially between sham and PRATA groups. The expression levels are indicated by the increased gradient of dark blue to light blue to red intensity. c, d GO enrichment analysis shows most of those upregulated genes are associated with neuron plasticity and development, and those downregulated genes are prone to RNA processing and would healing. e, f Test of differential expressed gene abundances using g:Profile showed that up-regulated genes mainly involved in neuron activities, while the downregulated genes enriched for RNA activities in post-PRATA SHRs compared with sham-operated SHRs.