Table 2.
Geometry design principles of passive and label-free microfluidics
| Designing principles | Subprinciples | Examples |
|---|---|---|
| Shape modification | Parametric optimization | DLD pillar size and gap optimization |
| IMF/VEM rectangular cross section modification | ||
| Shape optimization | DLD pillar shape optimization | |
| IMF channel direction modification | ||
| IMF channel cross section shape optimization | ||
| Topology modification | Structural simplification | Simplified DLD |
| Topology optimization | Topology-optimized DLD pillar | |
| Topology-optimized IMF channel | ||
| Combination | Combination within the same scheme | Cascaded/mirrored DLD array |
| Duplicated PFF | ||
| Combination of spiral and serpentine IMF channels | ||
| Combination of different schemes | DLD array before an IMF focusing channel | |
| IMF channel before a DLD array | ||
| DLD array with viscoelastic fluid | ||
| 3D structure | 3D structure | 3D DLD |
| 3D IMF channel | ||
| Top and bottom wall modification | Hydrophoresis |