Table 5.

Association of DCDC2 mRNA levels with cognitive and pathological phenotypes in the ROSMAP cohort.

Trait	n	logFC	t	P	Padj	FDRPadj
Slope of global cognition	661	1.10	4.73	2.8E-06	7.4E-05	0.002
Slope of episodic memory	660	0.97	4.31	1.9E-05	3.8E-04	0.004
Neuronal neurofibrillary tangles	691	−0.06	−3.70	2.3E-04	0.003	0.021
Amyloid beta protein	692	−0.06	−3.26	0.001	0.008	0.042
Neurofibrillary tangle burden	698	−0.17	−3.32	0.001	0.009	0.038
Neuritic plaque burden	698	−0.13	−3.17	0.002	0.011	0.039
Pathological AD diagnosis	698	−0.11	−3.46	0.001	0.012	0.036
Global measure of pathology	698	−0.10	−2.88	0.004	0.024	0.063
Neuronal loss substantia nigra	696	−0.08	−2.97	0.003	0.026	0.061
Transactive response DNA binding protein	640	−0.05	−2.50	0.013	0.138	0.290
Pathologic diagnosis of Lewy body diseases	674	−0.04	−2.07	0.039	0.332	0.634
Diffuse plaque burden	698	−0.06	−1.47	0.142	0.455	0.796
Global Parkinsonian Summary Score	696	−0.03	−1.81	0.071	0.482	0.779
Arteriolosclerosis	692	−0.03	−1.37	0.173	0.665	0.998
Any distribution of α-synuclein	674	−0.06	−1.78	0.075	0.668	0.935
Gross cerebral infarctions	698	0.03	0.93	0.354	0.798	1.047
Micro cerebral infarctions	698	−0.03	−1.03	0.303	0.821	1.014
Cerebral amyloid angiopathy	683	−0.02	−0.71	0.481	0.875	1.021
Diagnosis of Parkinson	695	0.03	0.48	0.630	0.891	0.985
Hippocampal sclerosis	694	−0.04	−0.80	0.423	0.898	0.943
Cerebral Atherosclerosis	695	0.00	0.17	0.863	0.964	0.964