TABLE 2.

Specific G6PD variants that have been reported to be associated with neonatal hyperbilirubinemia.

G6PD variant	cDNA nucleotide substitution	Amino acid substitution	Mutation class	References
Nashville, Anaheim, Portici	1178G > A	Arg393His	I	(95)
Campinas	1463G > T	Gly488Val	I	(95)
Harilaou	648T > G	Phe216Leu	I	(95)
Volendam	514C > T	Pro172Ser	I	(95)
Canton, Taiwan-Hakka, Gifu-like, Agrigento-like	1376G > T	Arg459Leu	II	(14)
Kaiping, Anant, Dhon, Sapporo-like, Wosera	1388G > A	Arg463His	II	(14)
Gaohe	95A > G	His32Arg	II	(14)
Viangchan, Jammu	871G > A	Val291Met	III	(14, 96)
Mahidol	487G > A	Gly163Ser	III	(14, 96)
Mediterranean, Dallas, Panama, Sassari	563C > T	Ser188Phe	II	(14, 96–98)
Orissa	131C > G	Ala44Gly	III	(99)
A–202A/376G	202G > A 376A > G	Val68Met, Asn126Asp	III	(96)
A–376G/968C, Betica, Selma, Guantanamo	376A > G 968T > C	Asn126Asp, Leu323Pro	III	(96)
Union, Maewo, Chinese-2, Kalo	1360C > T	Arg454Cys	II	(96)
Akrokorinthos	463C > G	His155Asp	II-III	(96)
Belem	409C > T	Leu137Phe	II	(96)
Santamaria	376A > G 542A > T	Asn126Asp, Asp181Val	II	(96)
Hamburg	827C > T	Pro276Leu	I	(100)
Herlev	592C > A	Arg198Ser	I-II	(101)