FIGURE 3.

Blocking P2X7 receptor with AZ 10606120 does not prevent vascular injury during murine sepsis. Mice were subjected to cecal slurry (CS) to induce sepsis in the presence or absence of 1‐h pre‐treatment with AZ 10606120 (AZ; 10 µg/g, SQ) for 24 h. Circulating markers of vascular injury (plasma), including (a) E‐selectin, (b) ICAM‐1, (c) PECAM‐1, (d) PAI‐1, (e) thrombomodulin, or (f) pro‐MMP‐9, were not reduced with AZ 10606120 treatment in mice subjected to CS. Statistical analysis was performed using one‐way ANOVA with Tukey's multiple comparisons. Graphs represent mean ± SEM (n = 9–14)