FIGURE 6.

Blocking P2X7 receptor with AZ 10606120 does not prevent illness severity or bacterial load during murine sepsis. Mice were subjected to cecal slurry (CS) to induce sepsis in the presence or absence of 1‐h pre‐treatment with AZ 10606120 (AZ; 10 µg/g, SQ) for 24 h. AZ 10606120 treatment did not reduce (a) sepsis illness severity (sepsis score, n = 30–42) or bacterial load (CFU) of the (b) lung (n = 8–16) or (d) spleen (n = 8–16). Conversely, spleen bacterial load worsened with AZ 10606120 treatment. Statistical analysis was performed using one‐way ANOVA with Tukey's multiple comparisons. Graphs represent mean ± SEM