TABLE 3.

A list of studies reporting the TRP ion channel drug discovery using techniques other than Ion Channel Reader (ICR) technology.

TRP Ion Channel	Technique used	Model	Drug, agonist antagonist	Reference
TRPM2	Ca2+-sensitive fluorescence dye, Fluo-4 NW	Novel suspension B lymphocyte cell line	TRP channel modulator	Song et al. (2008)
TRPC4	Whole-cell patch-clamp	HEK293 cells	ML204, antagonist	Miller et al. (2011)
TRPM8	QPatch HT	Menthol activated ion channel	Antagonist	Beck et al. (2010)
TRPM7	Mn2+ sensitive fluorescent dye	HEK293 cells	Antagonist	Castillo et al. (2010)
TRPV1 and TRPM8	Ca2+-sensitive fluorescence dye, Fluo-4 NW	Puro MEM culture media	Antagonist	Cordero-Sanchez et al. (2019)
TRPM8	Radiometric Calcium imaging and electrophysiology using FLIPR	cold, voltage, and phosphatidylinositol-4,5-bisphosphate activated ion channel	Agonist	Bandell et al. (2006)
TRPV1	Automated patch clamp	TRPV1-null mice	Antagonist	Zicha et al. (2013)