TABLE 3.

Physician’s global assessment at 2 weeks after the last treatment.

	No or minimal improvement	Moderate improvement	Marked improvement	Excellent improvement	P-value
Physician’s global assessments for brightness (n)					0.001*
MN alone	5	18	5	0
MN plus hUC-MSCs-CM	0	17	11	0
Physician’s global assessments for skin texture (n)					0.000*
MN alone	6	15	7	0
MN plus hUC-MSCs-CM	2	13	7	6

Physician’s global assessments: grade 1: 0–25% = minimal or no improvement; grade 2: 26–50% = moderate improvement; grade 3: 51–75% = marked improvement; and grade 4: 75–100% = excellent improvement. MN: microneedling; hUC-MSCs-CM: human umbilical cord-derived mesenchymal stem cells conditioned media.

*P < 0.05.