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. 2022 May 24;9:858977. doi: 10.3389/fmed.2022.858977

Table 5.

Effectiveness of fertility awareness-based methods in women or couples with subfertility trying to conceive.

N Population Mean women's age (years); % prior birth; prior time trying Study design FABM Medical interventions Live birth or pregnancy rates References
370 Massachusetts, USA 34.8 years
27%
2.7 years
Cohort Creighton Model or Sympto-thermal Multiple medical interventions; subset had surgery for endometriosis Adjusted 29% live birth rate with up to 2 years of treatment; 40% for women with BMI <25 Stanford et al. (81)
384 Australia 33.1 years
Unknown prior birth
51% had tried >1 year
Cohort Billings None stated Women with good cervical fluid: 76% pregnant in 2 years; poor cervical fluid: 44% in 2 years Marshell et al. (82)
403 Ireland 37.2 years
22%
5.8 years
Cohort Creighton Model Multiple medical interventions; subset had surgery for endometriosis Adjusted 32% live birth rate with up to 2 years of treatment; 33% for women with 3 or more ART attempts Boyle et al. (80)
187 Heidelberg, Germany 34.7 years
15%
3.5 years
Cohort Sensiplan None Adjusted pregnancy rate 38% at 8 months Frank-Herrmann et al. (83)
108 Toronto, Canada 35.4 years
20%
3.2 years
Cohort Creighton Model Multiple medical interventions; subset had surgery for endometriosis Adjusted 66% live birth rate with up to 2 years of treatment Tham et al. (84)
1,072 Galway, Ireland 35.8 years
24%
5.6 years
Cohort Creighton Model Multiple medical interventions; subset had surgery for endometriosis Adjusted 53% live birth rate with up to 2 years of treatment Stanford et al. (85)