TABLE 2.
Univariable and multivariable logistic regression analysis for prediction of survival in GEO and ArrayExpress databases.
| Dataset | Factors | Subgroup | Univariable analysis | Multivariable analysis | ||
|---|---|---|---|---|---|---|
| OR (95%CI) | p | OR (95%CI) | p | |||
| GSE65682 | — | — | — | — | — | — |
| Age | — | 1.02 (0.99–1.04) | 0.114 | NA | NA | |
| Sex | Female | 1 | — | — | — | |
| Male | 1.42 (0.75–2.67) | 0.284 | NA | NA | ||
| MARS | 1–2 | 1 | — | — | — | |
| — | 3–4 | 0.93 (0.67–1.31) | 0.688 | NA | NA | |
| DM | No | 1 | — | — | — | |
| — | Yes | 1.63 (0.71–3.74) | 0.248 | NA | NA | |
| HLA score | — | 5.13 (2.03–15.39) | <0.001* | 5.13 (2.03–15.39) | <0.001* | |
| GSE63042 | — | — | — | — | — | — |
| HLA score | — | 1.35 (4.22–43.18) | <0.001* | 1.35 (4.22–43.18) | <0.001* | |
| GSE54514 | — | — | — | — | — | — |
| HLA score | — | 1.19 (1.06–1.45) | 0.006* | 1.19 (1.06–1.45) | 0.006* | |
| GSE95233 | — | — | — | — | — | — |
| Age | — | 0.99 (0.95–1.03) | 0.657 | NA | NA | |
| Sex | Female | 1 | — | — | — | |
| — | Male | 0.65 (0.35–1.18) | 0.156 | NA | NA | |
| HLA score | — | 15.68 (3.04–80.93) | <0.001* | 15.68 (3.04–80.93) | <0.001* | |
| E-MTAB-4421 | — | — | — | — | — | — |
| Age | — | 1.05 (1.02–1.07) | <0.001* | 1.05 (1.03–1.08) | <0.001* | |
| Sex | Female | 1 | — | — | — | |
| — | Male | 1.16 (0.64–2.10) | 0.620 | NA | NA | |
| SRS | 1 | — | — | — | — | |
| — | 2 | 1.77 (0.98–3.20) | 0.060 | NA | NA | |
| HLA score | — | 2.68 (1.44–4.97) | 0.002* | 2.93 (1.53–5.58) | 0.001* | |
| E-MTAB-4451 | — | — | — | — | — | — |
| Age | — | 1.00 (0.98–1.03) | 0.934 | NA | NA | |
| Sex | Female | 1 | — | — | — | |
| — | Male | 0.95 (0.40–2.28) | 0.913 | NA | NA | |
| SRS | 1 | — | — | — | — | |
| — | 2 | 2.70 (1.18–6.19) | 0.019 | 1.35 (0.50–3.70) | 0.555 | |
| HLA score | — | 5.69 (2.08–15.58) | 0.001* | 5.69 (2.08–15.58) | 0.001* | |
| E-MTAB-7581 | — | — | — | — | — | — |
| Age | — | 1.02 (0.99–1.04) | 0.091 | NA | NA | |
| Sex | Female | 1 | — | — | — | |
| — | Male | 1.39 (0.71–2.72) | 0.343 | NA | NA | |
| SRS | 1 | — | — | — | — | |
| — | 2 | 1.31 (0.68–2.55) | 0.423 | NA | NA | |
| APACHE II | — | 1.08 (1.04–1.13) | 0.001* | 1.24 (1.06–1.19) | 0.001* | |
| HLA score | — | 11.35 (3.85–33.44) | <0.001* | 17.74 (5.37–58.66) | <0.001* | |
Abbreviations: OR, odds ratio; CI, confidence intervals; MARS, the Molecular Diagnosis and Risk Stratification of Sepsis; DM, diabetes mellitus, APACHE II, acute physiology and chronic health evaluation; SRS, sepsis response signature. NOTE: NA, not available. These variables were eliminated in the multivariate logistic regression model, so the HR, and p values were not available. *p < 0.05.