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. 2022 May 24;14:826601. doi: 10.3389/fnsyn.2022.826601

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Copyright © 2022 Smith, Goodman and McMahon.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Voltage sag potential is decreased in TgF344-AD DGCs. (A) Example trace of “sag” current measurements taken at −400 pA current injection. (B) The raw amplitude of the sag current is not different between TgF344-AD and Wt littermate DGCs (Wt, n = 21 cells/8 animals; Tg, n = 12 cells/6 animals; p > 0.05). (C) The voltage response at −400 pA is greater in TgF344-AD rats (Wt, n = 22 cells/8 animals; Tg, n = 13 cells/6 animals; *p < 0.05). (D) When sag amplitude is normalized to voltage response a significant deficit in TgF344-AD DGC sag is unmasked (Wt, n = 21 cells/8 animals; Tg, n = 12 cells/6 animals; *p < 0.05). Data represent mean ± SEM. Significance is determined using the unpaired Student's t-test.