Table 3.

Adherence outcomes by study arm (Triggered escalating real-time adherence intervention (TERA) versus standard of care (SOC))

Adherence summary	Weeks	SOC median (Q1, Q3)	TERA median (Q1, Q3)		pa
% doses taken (PCT12)	0–12	41 (21, 59)	72 (47, 89)		< 0.001
	13–24	14 (1, 32)	41 (11, 70)		< 0.001
	25–36	2 (0, 14)	17 (2, 41)		0.06

Adherence summary	Weeks	IR (95% CI)	IR (95% CI)	TERA to SOC IR Ratiob	pb
GAP IR	0–12	4.2 (3.6, 4.8)	1.7 (1.3, 2.1)	0.40 (0.30, 0.53)	< 0.001
	13–24	6.9 (6.2, 7.8)	4.4 (3.8, 5.2)	0.64 (0.53, 0.77)	< 0.001
	25–36	8.2 (7.3, 9.2)	6.7 (5.8, 7.6)	0.81 (0.68, 0.97)	0.02

PCT12 percent doses taken over the 12-week period, IR incidence rate

$\text{GAP IR}=12\ast \frac{\text{Number of seven day gaps in EDM opening}}{\text{Number of weeks with data}}$

^aWilcoxon p-value

^bWald confidence intervals and p-values from generalized linear model with Poisson link