Figure 3.

Partial amelioration of dystrophic muscle histopathology following μDys, but not CRISPR treatment

CRISPR- versus μDys-treated muscle sample cross sections from the 3-year-old dog (exhibiting dystrophin expression in Figure 2), stained with hematoxylin and eosin to reveal myofibers (pink) and cell nuclei (blue) (H&E; left columns) or stained with picrosirius red to reveal myofibers (orange) and collagen/fibrotic tissue (red) (right columns). Images located in the top or bottom rows were acquired from the same muscle samples at 100×- and 400× magnification, respectively. Scale bars, 100 μm.