Figure 7.

Depletion of LINC01234 suppresses HCC growth in vivo and enhances the antitumor efficacy of sorafenib

(A) Tumor formation was performed in nude mice injected with LINC01234 shRNA1, LINC01234 shRNA2, or control cells (n = 6).

(B) The volume of xenograft obtained in (A) was measured and summarized.

(C) The weight of xenograft obtained in (A) was measured and summarized.

(D) The Ki67 expression was evaluated and summarized by immunohistochemistry in the mouse xenografts. Scale bar, 20 μm.

(E) The ASS1 level of xenografts were detected by western blot.

(F) The HCC cells were treated with sorafenib as indicated. Then, the cell number was evaluated by MTT assay.

(G) Colony number quantification of the HepG2 cells was determined after treatment with sorafenib.

(H) Colony number quantification of the Huh7 cells was determined after treatment with sorafenib. See also Figure S3.