TABLE 3.

Top 10 substances in the order of Fold Change by multiple comparison test on intracellular metabolites.

	WT vs. Δ Clpks18_VIP	Mean_WT	SD_WT	Mean_Δ Clpks18	SD_Δ Clpks18	Fold change	p-value	FDR
(R)-(-)-Mellein	1.72	3,373,640	1,121,464	185,425	5,950	18.19	0.00	0.00
Ser-His-OH	1.39	2,261,011,817	1,538,157,386	177,076,864	123,599,794	12.77	0.01	0.04
Melibiose	1.19	94,828,462	83,018,414	8,359,615	6,409,352	11.34	0.03	0.09
Glycine betaine	1.46	5,044,618,292	2,177,464,722	1,446,366,720	983,723,002	3.49	0.00	0.03
Creatine	1.19	89,141,346	57,738,346	25,857,899	18,133,344	3.45	0.03	0.09
Dicyclomine	1.47	77,082,871	7,394,681	58,482,891	9,805,145	1.32	0.00	0.03
12-Oxo-2,3-Dinor-10,15-Phytodienoic acid	1.57	3,055,430	174,070	2,677,602	93,334	1.14	0.00	0.01
	OE-Clpks18 vs. ΔClpks18_VIP	Mean_OE-Clpks18	SD_OE-Clpks18	Mean_ΔClpks18	SD_ΔClpks18	Fold change	p-value	FDR
(R)-(-)-Mellein	2.34	2,087,784	608,940	185,425	5,950	11.26	0.00	0.01
2-Hydroxycinnamic acid	2.25	20,989,628	4,617,226	7,100,966	3,108,265	2.96	0.00	0.02
cis-9,10-Epoxystearic acid	1.73	17,488,636	8,815226	6,192,771	3,004,008	2.82	0.01	0.19
Glycine betaine	1.69	3254,280,581	1,481,103,965	1,446,366,720	983,723,002	2.25	0.03	0.41
Homovanillic acid	2.06	20,272,674	4,962,582	9,480,956	3,281,891	2.14	0.00	0.07
9,10-DiHOME	1.51	394,895,243	145,578,924	207,924,102	129,879,481	1.90	0.04	0.30
Pinolenic acid	1.63	801,815,554	298,787,954	441,518,658	227,696,267	1.82	0.04	0.45
Dibutyl phthalate	1.66	109,020,376	23,779,796	66,554,880	35,613,748	1.64	0.04	0.42
Allantoin	1.80	183,955,689	31,513,853	119,051,071	38,350,076	1.55	0.01	0.16
12-Oxo-2,3-Dinor-10,15-Phytodienoic Acid	1.91	2,879,035	97,364	2,677,602	93,334	1.08	0.00	0.13