Table 1.
The expression and roles of FHL3 in different human cancers.
| Cancer type | Levels | Function | Target genes/related proteins | Ref. |
|---|---|---|---|---|
| Hepatocellular cancer (HC) | Down | Inhibit cell growth | p21 and c-myc | (17) |
| Breast cancer (BC) | Down | Suppress cell growth and induce cell-cycle stagnation at g1 and g2/m phases | p21, cyclin D1 and cyclin B1 | (30) |
| Gastric cancer (GC) | Up | Promote metastasis and emt-mediated tumor invasion | Slug | (31) |
| Glioma stem cell (GSC) | Up | Suppress cell growth, proliferation, and self-renewal | SOX4 and SOX2 | (32–34) |
| Pancreatic ductal adenocarcinoma (PDAC) | Up | Inhibit migration promote cell growth and metastasis | snail1 and twist1 | (35) |
| Non‐small cell lung cancer (NSCLC) | Up | Promote cell growth, proliferation, and invasion | P27, TGF-β, and Smad2/3 | (36) |
| T-cell leukemia (ATL) | Up | Increase the mobility of HTLV-1-infected and -transformed cells | TAX1 | (37) |
| A673 neuroepithelioma cells | Up | Promote the expression of nNOS | cAMP, CREB and CREM | (38) |
| Tumor angiogenesis | Up | Inhibit tumor growth and progression | HIF-1 | (39,40) |