TABLE 2.
Characteristics of the studied population and differential PfMDR1 N86Y and PfCRT K76T SNP distribution.
| Total (N=48) | PfMDR1 N86 (n=10)* | PfMDR1 Y86 (n=25)* | P value | PfCRT K76 (n=23)* | PfCRT T76 (n=15)* | P value | |
|---|---|---|---|---|---|---|---|
| Mean ± SD (min - max) | Mean ± SD | Mean ± SD | Mean ± SD | Mean ± SD | |||
| Age (months) | 49.88 ± 29.68 (12 - 119) | 45.00 ± 23.19 | 50.52 ± 33.00 | 0.89 | 58.22 ± 32.54 | 35.47 ± 22.97 | 0.04 |
| Weight (kg) | 14.24 ± 5.46 (8 - 30) | 12.70 ± 3.34 | 14.15 ± 6.12 | 0.92 | 16.12 ± 6.49 | 11.53 ± 2.83 | 0.03 |
| Parasitemia # | 60.51 ± 51.30 (2.12 – 200.4) | 79.14 ± 60.51 | 65.04 ± 54.32 | 0.66 | 68.89 ± 58.25 | 56.61 ± 51.87 | 0.91 |
| Hemoglobin | 100.50 ± 16.88 (71 - 134) | 103.6 ± 19.75 | 97.64 ± 14.34 | 0.33 | 103.90 ± 19.51 | 91.87 ± 12.24 | 0.07 |
| Temperature (°C) | 37.91 ± 0.97 (36.20 - 40.80) | 38.51 ± 1.21 | 37.70 ± 0.97 | 0.06 | 38.03 ± 1.14 | 37.53 ± 0.57 | 0.37 |
| Slope half-life | 2.49 ± 1.12 (0.54 - 5.21) | 2.36 ± 1.46 | 2.64 ± 1.10 | 0.48 | 2.50 ± 1.13 | 2.41 ± 1.34 | 0.97 |
| PC50 (h) | 6.00 ± 3.13 (0.80 - 14.78) | 6.48 ± 2.57 | 6.09 ± 3.31 | 0.62 | 5.67 ± 2.46 | 5.69 ± 3.63 | 0.94 |
| PC90 (h) | 11.60 ± 4.79 (2.07 - 21.80) | 11.95 ± 4.63 | 11.87 ± 5.01 | 0.87 | 11.47 ± 4.06 | 10.73 ± 6.03 | 0.80 |
| PC95 (h) | 14.09 ± 5.68 (2.61 - 26.18) | 14.31 ± 5.91 | 14.52 ± 5.84 | 0.87 | 13.96 ± 5.02 | 13.13 ± 7.13 | 0.87 |
| PC99 (h) | 19.87 ± 7.96 (3.86 - 37.84) | 19.79 ± 9.08 | 20.65 ± 8.02 | 0.58 | 19.76 ± 7.44 | 18.72 ± 9.91 | 0.91 |
*Mixed infections excluded from statistical calculations.
#Pf/mm3 of blood