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. 2022 May 24;9:895927. doi: 10.3389/fmolb.2022.895927

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Copyright © 2022 Wang, Guo, Jiang, Wang, Pan, Nie and Jiang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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lncRNA-AP000695.2 promotes LUAD cell proliferation, migration, and invasion in vitro. (A) Relative expression level of lncRNA AP000695.2 in lung adenocarcinoma cancerous cell lines, including H1650, H1975, and H1299 examined by real-time RT-PCR, compared with normal human bronchial epithelial cell lines: BEAS-2B. (B–C) Establishment of lncRNA-AP000695.2 knockdown cell lines in H1299 and H1975 cells verified by real-time RT-PCR. (D–E) Knockdown of lncRNA-AP000695.2 significantly inhibits cell proliferation in H1299 and H1975 cells as measured by BrdU and colony formation. (F–G) Knockdown of lncRNA AP000695.2 dramatically inhibits H1299 and H1975 cells’ migration ability examined by transwell and wound healing assays. *p < 0.05, **p < 0.01, and ***p < 0.001.