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. 2022 May 24;9:895927. doi: 10.3389/fmolb.2022.895927

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Copyright © 2022 Wang, Guo, Jiang, Wang, Pan, Nie and Jiang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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lncRNA-AP000695.2 contributes to DDP resistance of LUAD. (A) Relationships between AP000695.2 expression and different drugs were examined by the GDSC database. (B) Expression of AP000695.2 in DDP-resistant and matched parental LUAD cells, normalized to 18sRNA expression. (C) AP000695.2 knockdown increases the sensitivity of H1299/CDDP-resistant cells to CDDP, detected by CCK-8 assay. (D–E) AP000695.2 knockdown increases the CDDP-induced apoptosis rate in H1299/DDP-resistant cells detected by FCM.