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. 2022 May 24;16:872509. doi: 10.3389/fnins.2022.872509

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Copyright © 2022 Chen, Marquez-Nostra, Belitzky, Toyonaga, Tong, Huang and Cai.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) [¹¹C]PIB binding to Aβ deposits varies by mouse strains. APP23: Extensive Aβ deposits; Tg2576: Mild Aβ deposits; APP-swePS1dE9: Extensive Aβ deposits. This figure was adapted and modified from Snellman et al. J Nucl Med. 2013;54:1434-1441. (B) Uptake of the SV2A PET tracers [¹¹C]UCB-J and [¹⁸F]SynVesT-1 in the brain of APP/PS1 and wild-type mice. The uptake of both tracers was lower in the hippocampus of APP/PS1 mice compared to wild-type controls.