Figure 6. CD36 is required for the pathogenic role of KLF10 in promoting NASH.

• A–G
  6‐week‐old male CD36 wild‐type (WT) or knockout mice (CD36^KO) were administered with AAV‐GFP (Ctrl) or AAV‐KLF10 (KLF10^OE) through tail vein injection, and then kept on WD/CCl₄ for 12 weeks. n = 5 per group. (A) Protein levels of KLF10 and CD36 in the liver (left), and their normalization to β‐actin (right). (B) Representative immunofluorescence staining of KLF10 and CD36 (left), and the quantitative results (right). (C) H&E and Sirius red staining of liver sections. (D) Quantitative results of Sirius red staining. (E) Body weights and liver/body weight ratio. (F) Hepatic TG contents. (G) Serum AST and ALT levels.

Data information: *P < 0.05, **P < 0.01, ***P < 0.001. Results are shown as mean ± SD. One‐way ANOVA (A, B, D–G).

Source data are available online for this figure.