Figure 4. Functional clusters extracted from HCI cross‐correlation analysis.

1. HCI–HCI association clusters identified via cross‐correlation analysis of the identified RTK interactors. Clusters represent proteins, which are often co‐purified in our experiments. Clusters were identified separately from the AP‐MS or the BioID cross‐correlation data. RTKs, if any, in the clusters are shaded light blue.
2. Enriched (log2FC > 5, q < 0.05, calculated with Fisher exact test and Benjamini–Hochberg multiple‐testing correction using the human UniProt as reference) reactome pathways in the identified association cluster. Nodes downstream from the signal transduction root node are shown. Node size corresponds to log2 fold change value of the pathway. Three pathway groups where AP‐MS and BioID clusters had the most prominent differences in enrichment are further highlighted in the boxes with orange (AP‐MS) and blue (BioID) background on the right.