Table 1.
Summary of Green-synthesized AgNPs structures with anti-leukemic applications.
| Biological source | Size (nm) | Leukemia cell line | Dose | IC50 value | Ref |
|---|---|---|---|---|---|
| Spinacia oleracea | 20 - 40 | 32D-FLT3-ITD&Human HL-60/vcr Murine C1498 | 0–1000 µg/mL | 214 µg/mL 238 µg/mL 217 µg/mL | [94] |
| Glycyrrhiza glabra | 20 | J45.01 Jurkat Clone E6–1 J.CaM1.6, J.RT3.T3.5 | 0–1000 µg/mL | 329 µg/mL 284 µg/mL 226 µg/mL 270 µg/mL | [95] |
| Melissa officinalis | 5 – 30 | 32D-FLT3-ITD Human HL-60/vcr Murine C1498 | 0–1000 µg/mL | 325 µg/mL 272 µg/mL 188 µg/mL | [96] |
| Boswellia dalzielii | 12 – 101 | Kasumi 1 | 0–70 μg/ml | 49.5 µg/mL (24 h) 13 µg/mL (72 h) | [97] |
| A. millefolium | 22.4 ± 7.4 | MOLT-4 | 0.004–0.1 µM | 0.011 uM | [98] |
| Nyctanthes arbortristis | 12 - 22 | THP-1 | 5–50 µg/ml | 30 – 40 µg/mL | [99] |
| Sargassum Vulgare | 7 - 12 | HL60 | 0.2–100 µg/ml | 2.84 µg/mL | [100] |
| Azadirachta indica | 20–50 nm | human acute lymphocytic leukemia (ALL) | 15.6–250 µg/mL | Around 40% cell inhibition was found at 250 µg/mL | [101] |
| Calotropis gigantea | Average: 2.338 nm | Jurkat | 0.5–10 µg/mL | 11.99 µg/mL | [102] |
| Nathophodytes foetida | No data | K-562 | 1–30 µg/mL | 10 µg/mL | [103] |
| Nothapodytes foetida | 10–50 nm | K-562 | 1–30 µg/mL | 6.17 µg/mL | [104] |
* Abbreviations: murine AML cell line from C57BL/6 mouse (C1498); Human leukemia cells HL60 (HL60); murine myeloid progenitor 32D cells that ectopically express human FLT3-ITD (32D- FLT3-ITD); T lymphoblast ALL derived cells MOLT-4 (MOLT-4); Human myeloblast AML derived cells (Kasumi 1); human bone marrow lymphoblast CML derived cells (K562); human AML monocytes (THP-1); derivative mutant of the Jurkat leukemia cell line (J .RT3 -T3.5); immortalized line of human T lymphocyte cells (Jurkat); derivative mutant of Jurkat (J.CaM1.6).