Table 1.
Drugs Listed in CPIC Guidelines Only, Both CPIC Guidelines and FDA Table, and FDA Table Only
| CPIC Guidelines Only (n = 20) | CPIC Guidelines and FDA Tablea (n = 39) | FDA Table Only (n = 67) |
|---|---|---|
| Data Support Therapeutic Management Recommendations | ||
| Atazanavir | Abacavir | Amifampridine |
| Desflurane | Atomoxetine | Amifampridine phosphate |
| Enflurane | Azathioprine | Amphetamine |
| Fosphenytoin | Capecitabine | Aripiprazole |
| Halothane | Carbamazepine | Aripiprazole lauroxil |
| Hydrocodone | Celecoxib | Belinostat |
| Isoflurane | Citalopram | Brexpiprazole |
| Ivacaftor | Clopidogrel | Brivaracetam |
| Lansoprazole | Codeine | Clobazam |
| Lornoxicam | Fluorouracil | Clozapine |
| Methoxyflurane | Flurbiprofen | Deutetrabenazine |
| Ondansetron | Meloxicam | Dronabinol |
| Peginterferon alfa-2a | Mercaptopurine | Eliglustat |
| Peginterferon alfa-2b | Pantoprazole | Erdafitinib |
| Phenytoin | Piroxicam | Flibanserin |
| Rasburicase | Succinylcholine | Gefitinib |
| Sertraline | Tacrolimus | Iloperidone |
| Sevoflurane | Thioguanine | Irinotecan |
| Tenoxicam | Tramadol | Lofexidine |
| Tropisetron | Warfarin | Meclizine |
| Metoclopramide | ||
| Mivacurium | ||
| Oliceridine | ||
| Pimozide | ||
| Pitolisant | ||
| Propafenone | ||
| Sacituzumab | ||
| Siponimod | ||
| Tetrabenazine | ||
| Thioridazine | ||
| Valbenazine | ||
| Venlafaxine | ||
| Vortioxetine | ||
| Potential Impact on Safety/Response | ||
| Allopurinol | Carvedilol | |
| Carbamazepineb | Cevimeline | |
| Codeineb | Isoniazid | |
| Efavirenz | Lapatinib | |
| Oxcarbazepine | Nilotinib | |
| Simvastatin | Pazopanib | |
| Voriconazole | Perphenazine | |
| Procainamide | ||
| Sulfamethoxazole/ trimethoprim | ||
| Sulfasalazine | ||
| Tolterodine | ||
| Impact on PK Only | ||
| Amitriptyline | Amoxapine | |
| Clomipramine | Atorvastatin | |
| Desipramine | Avatrombopag | |
| Dexlansoprazole | Carisoprodol | |
| Doxepin | Darifenacin | |
| Escitalopram | Diazepam | |
| Fluvoxamine | Dolutegravir | |
| Ibuprofen | Donepezil | |
| Imipramine | Elagolix | |
| Nortriptyline | Esomeprazole | |
| Omeprazole | Fesoterodine | |
| Paroxetine | Galantamine | |
| Tamoxifen | Hydralazine | |
| Trimipramine | Metoprolol | |
| Mirabegron | ||
| Nebivolol | ||
| Propranolol | ||
| Protriptyline | ||
| Raltegravir | ||
| Rabeprazole | ||
| Risperidone | ||
| Rosuvastatin | ||
| Tamsulosin |
Abbreviations: CPIC, Clinical Pharmacogenetics Implementation Consortium; FDA, Food and Drug Administration; PK, pharmacokinetics.
aFor drugs in both CPIC guidelines and the FDA Table of Pharmacogenetic Associations, many had different dosing or use recommendations (these drugs are indicated by ochre color) or additional or different gene/drug associations mentioned in the CPIC and FDA sources (indicated by red).
bCodeine and carbamazepine are listed in two FDA sections but counted only once each in the overall count.