Table 2.

Multivariable Cox regression analysis of association between the combined measure of treatment intensity and adherence and MACE.

Variable	Overall cohort	2010–2013 subgroup	2014–2016 subgroup
10% increase in combined intensity-adherence	0.84 (0.82–0.86)*	0.84 (0.82–0.87)*	0.87 (0.83–0.92)*

CI: confidence interval; CKD: chronic kidney disease; HR: hazard ratio; LLT: lipid-lowering therapy; MACE: major cardiovascular events.

Note: Values are expressed as HR (95% CI). Model adjusted for the following covariates: initial use of high-intensity LLT; sex; hypertension; CKD stages 4–5; diabetes; Charlson comorbidity index; atrial fibrillation; year of follow-up. In addition, the model uses age as the time scale to control for age. The model incorporates stratification variables rather than covariates as necessary to handle issues related to non-proportionality of hazards. The length of follow-up was limited to 4 years to handle non-proportional hazards.

^*P < 0.01.