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. 2022 Mar 14;7(6):1229–1240. doi: 10.1016/j.ekir.2022.03.007

Figure 1.

Figure 1

Glomerular capillary alterations in each variant of FSGS. In the case of the tip variant (a, b), the tip lesions show disappearance of CD34+ glomerular endothelial cells and loss of glomerular capillary lumens with foam cell infiltration (arrow). In the collapsing variant (c, d), the glomerulus shows global loss of CD34+ glomerular endothelial cells with hyperplastic podocytes and collapsed glomerular capillaries. In the cellular variant (e, f), loss of glomerular capillary lumens with disappearance of CD34+ endothelial cells is observed in the segmental lesion with endocapillary proliferation (arrow). In the cases of PH variant (g, h) and NOS variant (i, j), CD34+ endothelial cells disappeare in the segmental sclerosis lesion and ECM accumulated around the collapsed capillaries (a, c, e, g, i: PAM stain, ×600; b, d, f, h, j: CD34 stain, ×600). ECM, extracellular matrix; FSGS, focal segmental glomerular sclerosis; NOS, not otherwise specified; PAM, periodic acid–methenamine silver; PH, perihilar.