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. 2022 Mar 14;7(6):1229–1240. doi: 10.1016/j.ekir.2022.03.007

Figure 3.

Figure 3

Visualization and quantitative analysis of glomerular capillary network using computer-assessed image analyzer. In the control glomeruli (a–c), FSGS-scl (−) glomeruli (d–f), and FSGS-scl (+) glomeruli (g–i), area of the glomerular tuft (dotted lines a, d, g), ECM area (b, e, h green areas), and area and number of the glomerular capillaries (c, f, I, green areas) are evaluated using a computer-assessed image analyzer. The glomerular capillary network lined with CD34+ glomerular endothelial cells (a) and capillary area (c) is well preserved without ECM accumulation (b). In contrast, narrowing and decrease of glomerular capillaries with ECM accumulation are apparent in FSGS-scl (+) glomeruli (g–i). Even in the FSGS-scl (−) glomeruli (d–f), glomerular capillary lumens are clearly narrowed compared with the control glomeruli. ECM, extracellular matrix; FSGS, focal segmental glomerular sclerosis; FSGS-scl(−), glomeruli without sclerotic lesions in FSGS; FSGS-scl(+), glomeruli with sclerotic lesions in FSGS.