Figure 2. Relative Hazard Ratios for Black vs Non-Black Participants Using Different Glomerular Filtration Rate (GFR) Estimating Equations Compared With 2009 eGFRcr(ASR) in Each Participating Cohort.
Estimates are the ratio of Black vs non-Black participant hazard ratio at eGFR of 60 mL/min/1.73 m2 using each equation compared with the corresponding hazard ratio for the 2009 eGFRcr(ASR) adjusted for age and sex. The 2021 eGFRcr(AS) results in a significant attenuation of racial differences compared with the 2009 eGFRcr(ASR) in 17 of 18 relative hazard ratios (95% CIs did not include 1.0). In contrast, for the 2012 eGFRcys(AS) and 2021 eGFRcr-cys(AS), 32 of 36 95% CIs for the relative hazard ratios contain 1.0. Risk ratios less than 1 represent underestimation compared with eGFRcr (age, sex, and race). The data are available in eTable 5 in Supplement 1. ARIC indicates Atherosclerosis Risk in Communities; AS, age and sex; ASR, age, sex, and race; CHS, Cardiovascular Health Study; CRIC, Chronic Renal Insufficiency Cohort; MDRD, Modification of Diet in Renal Disease; MESA, Multi-Ethnic Study of Atherosclerosis; NHANES, National Health and Nutrition Examination Survey; and REGARDS, Reasons for Geographic and Racial Differences in Stroke.