Table 2. Prevalence of Decreased eGFR and Age- and Sex-Adjusted Hazard Ratios of KFRT for Different GFR Estimating Equations, by Racea.
| Equation | Participant race | Prevalence in general population cohorts and their ratio by race, % (95% CI) | Hazard ratios of KFRT vs eGFR = 80 mL/min/1.73 m2 and their ratio by race (95% CI) | |||
|---|---|---|---|---|---|---|
| eGFR <30 mL/min/1.73 m2 | eGFR <60 mL/min/1.73 m2 | eGFR = 30 mL/min/1.73 m2 | eGFR = 60 mL/min/1.73 m2 | eGFR = 80 mL/min/1.73 m2 | ||
| 2009 eGFRcr (age, sex, and race) | Black | 1.7 (1.5-1.9) | 11 (11-12) | 119 (41-351) | 9.3 (4.9-17.9) | 3.7 (2.0-6.7) |
| Non-Black | 0.70 (0.61-0.78) | 12 (11-12) | 74 (35-160) | 3.3 (2.5-4.4) | 1 [Reference] | |
| Ratio, Black vs non-Black | 2.5 (2.0-2.9) | 0.98 (0.93-1.03) | 1.6 (1.1-2.3) | 2.8 (1.6-4.9) | 3.7 (2.0-6.7) | |
| 2021 eGFRcr (age and sex) | Black | 1.9 (1.7-2.2) | 15 (15-16) | 78 (27-226) | 5.1 (2.6-9.9) | 2.3 (1.2-4.2) |
| Non-Black | 0.52 (0.44-0.59) | 8.7 (8.4-9.0) | 74 (32-172) | 3.8 (2.6-5.7) | 1 [Reference] | |
| Ratio, Black vs non-Black | 3.8 (3.1-4.4) | 1.8 (1.7-1.8) | 1.0 (0.8-1.4) | 1.3 (0.8-2.1) | 2.3 (1.2-4.2) | |
| 2012 eGFRcys (age and sex) | Black | 2.7 (2.5-2.9) | 17 (16-17) | 84 (24-299) | 8.0 (3.6-17.8) | 3.2 (2.0-5.0) |
| Non-Black | 1.8 (1.7-1.9) | 18 (17-18) | 41 (14-126) | 2.7 (1.7-4.3) | 1 [Reference] | |
| Ratio, Black vs non-Black | 1.5 (1.3-1.7) | 0.95 (0.91-0.98) | 2.0 (1.0-4.0) | 3.0 (1.5-5.8) | 3.2 (2.0-5.0) | |
| 2021 eGFRcr-cys (age and sex) | Black | 2.2 (1.9-2.4) | 13 (13-14) | 119 (37-377) | 9.7 (5.0-18.9) | 2.9 (1.6-5.3) |
| Non-Black | 0.81 (0.72-0.90) | 11 (10-11) | 74 (32-170) | 3.5 (2.6-4.8) | 1 [Reference] | |
| Ratio, Black vs non-Black | 2.7 (2.3-3.1) | 1.2 (1.2-1.3) | 1.6 (1.1-2.4) | 2.8 (1.4-5.4) | 2.9 (1.6-5.3) | |
Abbreviations: cr, creatinine; cys, cystatin; eGFR, estimated glomerular filtration rate; KFRT, kidney failure with replacement therapy.
Total sample size of 56 090 for prevalence estimates in general population cohorts, and 45 311 in hazard ratio estimation of KFRT. Ratios in Black compared with non-Black participants are prevalence ratios for the first 2 data columns and hazard ratios for the last 3 columns, and calculated by dividing the estimate in Black participants by the estimate in non-Black participants. Note that the ratio of 2 hazard ratios with the same reference group, eg, non-Black participants at eGFR of 80 mL/min/1.73 m2, is itself a hazard ratio. For example, 1.6 is the hazard ratio of KFRT in Black compared with non-Black participants at an eGFRcr(ASR) of 30 mL/min/1.73 m2.