Table 3. Age- and Sex-Adjusted Hazard Ratios of All-Cause and Cardiovascular Mortality Across Different GFR Estimating Equations by Racea.
| Equations | Participant race | Hazard ratio vs eGFR = 80 mL/min/1.73 m2 and their ratio by race (95% CI) | |||||
|---|---|---|---|---|---|---|---|
| All-cause mortality | Cardiovascular mortality | ||||||
| eGFR = 30 mL/min/1.73 m2 | eGFR = 60 mL/min/1.73 m2 | eGFR = 80 mL/min/1.73 m2 | eGFR = 30 mL/min/1.73 m2 | eGFR = 60 mL/min/1.73 m2 | eGFR = 80 mL/min/1.73 m2 | ||
| 2009 eGFRcr (age, sex, and race) | Black | 3.3 (2.4-4.6) | 1.3 (1.2-1.5) | 1.1 (1.1-1.2) | 4.3 (2.4-7.7) | 1.8 (1.4-2.2) | 1.3 (1.2-1.6) |
| Non-Black | 3.0 (2.6-3.4) | 1.1 (1.0-1.2) | 1 [Reference] | 3.7 (2.9-4.7) | 1.3 (1.1-1.5) | 1 [Reference] | |
| Ratio, Black vs non-Black | 1.1 (0.9-1.4) | 1.2 (1.1-1.4) | 1.1 (1.1-1.2) | 1.2 (0.8-1.7) | 1.4 (1.1-1.7) | 1.3 (1.2-1.6) | |
| 2021 eGFRcr (age and sex) | Black | 3.0 (2.2-4.1) | 1.2 (1.1-1.3) | 1.1 (1.0-1.2) | 3.9 (2.3-6.6) | 1.5 (1.2-1.8) | 1.3 (1.1-1.4) |
| Non-Black | 3.3 (2.8-3.8) | 1.2 (1.1-1.3) | 1 [Reference] | 3.8 (3.0-4.8) | 1.4 (1.2-1.6) | 1 [Reference] | |
| Ratio, Black vs non-Black | 0.9 (0.7-1.2) | 1.0 (0.9-1.1) | 1.1 (1.0-1.2) | 1.0 (0.7-1.5) | 1.1 (0.9-1.3) | 1.3 (1.1-1.4) | |
| 2012 eGFRcys (age and sex) | Black | 4.4 (3.2-6.1) | 1.8 (1.5-2.1) | 1.4 (1.2-1.6) | 5.7 (3.5-9.2) | 2.4 (1.9-3.1) | 1.6 (1.4-1.9) |
| Non-Black | 3.8 (3.1-4.8) | 1.4 (1.3-1.6) | 1 [Reference] | 4.6 (3.5-6.0) | 1.7 (1.5-2.0) | 1 [Reference] | |
| Ratio, Black vs non-Black | 1.2 (0.8-1.6) | 1.2 (1.1-1.4) | 1.4 (1.2-1.6) | 1.2 (0.8-1.9) | 1.4 (1.2-1.7) | 1.6 (1.4-1.9) | |
| 2021 eGFRcr-cys (age and sex) | Black | 4.0 (2.9-5.5) | 1.6 (1.4-1.8) | 1.2 (1.1-1.3) | 5.1 (3.0-8.6) | 2.1 (1.6-2.6) | 1.4 (1.2-1.5) |
| Non-Black | 3.9 (3.3-4.5) | 1.4 (1.3-1.5) | 1 [Reference] | 4.5 (3.7-5.5) | 1.6 (1.4-1.9) | 1 [Reference] | |
| Ratio, Black vs non-Black | 1.0 (0.8-1.4) | 1.1 (1.0-1.2) | 1.2 (1.1-1.3) | 1.1 (0.7-1.7) | 1.3 (1.0-1.6) | 1.4 (1.2-1.5) | |
Abbreviations: cr, creatinine; cys, cystatin; eGFR, estimated glomerular filtration rate.
a
Total sample of 62 011 for hazard ratio estimation for all-cause mortality, and 61 062 for cardiovascular mortality. Ratios in Black compared with non-Black participants are hazard ratios, and calculated by dividing the estimate in Black participants by the estimate in non-Black participants. Note that the ratio of 2 hazard ratios with the same reference group, eg, non-Black participants at eGFR of 80 mL/min/1.73 m2, is itself a hazard ratio. For example, 1.2 is the hazard ratio of all-cause mortality in Black compared with non-Black participants at an eGFRcr(ASR) of 60 mL/min/1.73 m2.