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. Author manuscript; available in PMC: 2022 Jun 7.
Published in final edited form as: J Parkinsons Dis. 2020;10(4):1657–1673. doi: 10.3233/JPD-201961

Table 5 –

Iterative FOG vs noFOG categorization using a step-wise binary logistic regression model

Iteration Parameter set included
(see key for details)		 FOG %
correct		 noFOG %
correct		 Overall
% correct		 Significant variables in
iteration of model (p values)
1 Initial gait parameters 53.8% 80.6% 68.4% initial %CV SL (p=0.006)
2 initial levodopa 48.0% 75.0% 62.3% daily levodopa dose (p=0.012)
3 Initial cognitive scores 46.2% 74.2% 61.4% FAB (p=0.058)
4 Initial mood scores 54.5% 87.1% 73.6% Apathy score (p=0.002)
5 Initial sleep scores - - - none
6 Initial gait parameters
Initial levodopa		 56.0% 78.6% 67.9% initial %CV SL (p=0.011)
7 Initial gait parameters
Initial cognitive scores		 53.8% 80.6% 68.4% initial %CV SL (p=0.006)
8 Initial gait parameters
Initial mood scores		 54.5% 87.1% 73.6% apathy score (p=0.002)
9 Initial gait parameters
Initial sleep scores		 41.7% 83.9% 65.5% initial %CV SL (p=0.008)
10 Initial gait parameters
initial PDQ-39 scores		 70.8% 87.1% 80.0% initial mean SW (p=0.040)
initial PDQ-39 (p=0.002)
11 Initial gait parameters
Initial cognitive scores
Initial levodopa		 56.0% 78.6% 67.9% initial %CV SL (p=0.011)
12 Initial gait parameters
Initial cognitive scores
Initial levodopa
Initial mood scores		 57.1% 89.3% 75.5% apathy score (p=0.003)
13 Initial gait parameters
Initial cognitive scores
Initial levodopa
Initial PDQ-39 scores		 73.9% 89.3% 82.4% initial mean SW (p=0.027)
initial PDQ-39 (p=0.003)
14 Initial gait parameters
Initial cognitive scores
Initial levodopa
Initial mood scores
Initial PDQ-39 scores		 57.1% 89.3% 75.5% apathy score (p=0.003)
15 Initial gait parameters
Initial cognitive scores
Initial levodopa
Initial mood scores
Initial sleep scores		 57.1% 89.3% 75.5% apathy score (p=0.003)
16 Initial gait parameters
Initial cognitive scores
Initial levodopa
Initial mood scores
Initial sleep scores
Initial PDQ-39 scores		 57.1% 89.3% 75.5% apathy score (p=0.003)
17 Initial cognitive scores
Initial mood scores
Initial sleep scores
Initial PDQ-39 scores		 57.1% 79.2% 68.9% apathy score (p=0.006)
18 Delta gait parameters 65.4% 83.9% 75.4% delta mean SW (p=0.029)
delta mean SS% (p=0.003)
19 Delta gait parameters
Delta MoCA		 65.4% 83.9% 75.4% delta mean SW (p=0.029)
delta mean SS% (p=0.003)
20 Delta gait parameters
Delta levodopa		 65.4% 83.9% 75.4% delta mean SW (p=0.029)
delta mean SS% (p=0.003)
21 Delta gait parameters
Delta levodopa
Delta MoCA		 65.4% 83.9% 75.4% delta mean SW (p=0.029)
delta mean SS% (p=0.003)
22 Delta gait parameters
Initial gait parameters		 69.2% 83.9% 77.2% delta mean SS% (p=0.001)
delta CV SW (p=0.025)
initial CV SL (p=0.004)
23 Delta gait
Initial cognitive scores
Initial levodopa
Initial mood scores
Initial sleep scores
Initial PDQ-39 scores		 81.8% 93.5% 88.7% Delta mean SL (p=0.024)
Delta mean SW (p=0.068)
Delta CV Sw% (p=0.018)
Apathy (p=0.035)
PDQ-39 (p=0.019)
Scopa-Cog (p=0.056)
24 Delta gait parameters
Delta levodopa
Delta MoCA
Initial gait parameters		 69.2% 83.9% 77.2% Delta mean SS% (p=0.001)
Delta CV SW (p=0.025)
Initial CV SL (p=0.004)
25 Delta gait
Delta levodopa
Delta MoCA
Initial cognitive scores
Initial levodopa
Initial mood scores
Initial sleep scores
Initial PDQ-39 scores		 81.8% 93.5% 88.7% Delta mean SL (p=0.024)
Delta mean SW (p=0.068)
Delta CV Sw% (p=0.018)
Apathy (p=0.035)
PDQ-39 (p=0.019)
Scopa-Cog (p=0.056)
26 -Final Delta gait
Delta levodopa
Delta MoCA
Initial gait
Initial cognitive scores
Initial levodopa
Initial mood scores
Initial sleep scores
Initial PDQ-39 scores 		95.2% 96.4% 95.9% Delta mean SL (p=0.004)
Delta mean SW (p=0.023)
Delta CV Sw% (p=0.021)
Initial CV FL (p=0.040)
Initial mean Sw% (p=0.081)
Apathy (p=0.029)
Key: Initial gait parameters (initial mean and %CV: SL, SW, SV, ST, Sw%, SS%, FL, IP)
Initial cognitive scores (MoCA, SCOPA-Cog, FAB)
Initial mood scores (HAM-A, HAM-D, AES)
Initial sleep scores (Epworth, RBD)
Initial levodopa (total daily levodopa dose, duration on levodopa)
Delta gait parameters (delta mean and %CV: SL, SW, SV, ST, Sw%, SS%, FL, IP)
Delta levodopa (mean dose change per year)
PPV: positive predictive value