Optimization reaction conditions for the one-pot pseudo-three-component synthesis of 3a.

Entry	Catalyst	Catalyst loading (mg)	Solvent	Temperature conditions	Time (min)	Yield (%)
1	Fe3O4/f-MWCNT-CS-Glu/NiII	5	H2O	Reflux	10	95
2	Fe3O4/f-MWCNT-CS-Glu/NiII	4	H2O	Reflux	15	90
3	Fe3O4/f-MWCNT-CS-Glu/NiII	7	H2O	Reflux	10	95
4	Fe3O4/f-MWCNT-CS-Glu/NiII	5	CH3OH	Reflux	20	65
5	Fe3O4/f-MWCNT-CS-Glu/NiII	5	CH3CH2OH	Reflux	10	95
6	Fe3O4/f-MWCNT-CS-Glu/NiII	5	CH3CN	Reflux	120	35
7	Fe3O4/f-MWCNT-CS-Glu/NiII	5	EtOAC	Reflux	120	25
8	Fe3O4/f-MWCNT-CS-Glu/NiII	5	CH2Cl2	35 °C	120	20
9	Fe3O4/f-MWCNT-CS-Glu/NiII	5	n-Hexane	Reflux	120	10
10	Fe3O4/f-MWCNT-CS-Glu/NiII	5	Solvent-free	70 °C	15	95
11	Fe3O4/f-MWCNT-CS-Glu	5	H2O	Reflux	120	55
12	Fe3O4/f-MWCNT-CS	5	H2O	Reflux	120	55
13	Fe3O4/f-MWCNT	5	H2O	Reflux	120	50
14	Fe3O4	5	H2O	Reflux	120	—