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. 2022 Jun 7;12(26):16454–16478. doi: 10.1039/d1ra08454b

Optimization reaction conditions for the one-pot two-component synthesis of 5a.

graphic file with name d1ra08454b-u2.jpg
Entry Catalyst Catalyst loading (mg) Solvent Temperature conditions Time (min) Yield (%)
1 Fe3O4/f-MWCNT-CS-Glu/NiII 5 H2O 80 °C 20 98
2 Fe3O4/f-MWCNT-CS-Glu/NiII 4 H2O 80 °C 20 92
3 Fe3O4/f-MWCNT-CS-Glu/NiII 7 H2O 80 °C 20 98
4 Fe3O4/f-MWCNT-CS-Glu/NiII 5 CH3OH Reflux 30 84
5 Fe3O4/f-MWCNT-CS-Glu/NiII 5 CH3CH2OH Reflux 20 98
6 Fe3O4/f-MWCNT-CS-Glu/NiII 5 CH3CN Reflux 30 90
7 Fe3O4/f-MWCNT-CS-Glu/NiII 5 EtOAc Reflux 90 50
8 Fe3O4/f-MWCNT-CS-Glu/NiII 5 CH2Cl2 35 °C 120 25
9 Fe3O4/f-MWCNT-CS-Glu/NiII 5 n-Hexane Reflux 120 15
10 Fe3O4/f-MWCNT-CS-Glu/NiII 5 THF  Reflux 120 70
11 Fe3O4/f-MWCNT-CS-Glu/NiII 5 Solvent-free 70 °C 15 95
12 Fe3O4/f-MWCNT-CS-Glu 5 H2O 80 °C 120 30
13 Fe3O4/f-MWCNT-CS 5 H2O 80 °C 120 10
14 Fe3O4/f-MWCNT 5 H2O 80 °C 120 10
15 Fe3O4 5 H2O 80 °C 120 —