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. 2022 Jun 7;12(26):16454–16478. doi: 10.1039/d1ra08454b

Optimization reaction conditions for the one-pot pseudo-three-component synthesis of 7a.


Entry	Catalyst	Catalyst loading (mg)	Solvent	Temperature conditions	Time (min)	Yield (%)
1	Fe₃O₄/f-MWCNT-CS-Glu/Ni^II	10	H₂O	Reflux	120	50
2	Fe₃O₄/f-MWCNT-CS-Glu/Ni^II	10	CH₃OH	Reflux	40	70
3	Fe₃O₄/f-MWCNT-CS-Glu/Ni^II	10	CH₃CH₂OH	Reflux	40	78
4	Fe₃O₄/f-MWCNT-CS-Glu/Ni^II	10	CH₃CN	Reflux	180	65
5	Fe₃O₄/f-MWCNT-CS-Glu/Ni^II	10	EtOAc	Reflux	180	25
6	Fe₃O₄/f-MWCNT-CS-Glu/Ni^II	10	CH₂Cl₂	35 °C	120	10
7	Fe₃O₄/f-MWCNT-CS-Glu/Ni^II	10	n-Hexane	Reflux	180	20
8	Fe₃O₄/f-MWCNT-CS-Glu/Ni^II	10	THF	Reflux	120	30
9	Fe₃O₄/f-MWCNT-CS-Glu/Ni^II	10	Solvent-free	110 °C	40	96
10	Fe₃O₄/f-MWCNT-CS-Glu/Ni^II	5	Solvent-free	110 °C	40	82
11	Fe₃O₄/f-MWCNT-CS-Glu/Ni^II	15	Solvent-free	110 °C	40	96
12	Fe₃O₄/f-MWCNT-CS-Glu	10	Solvent-free	110 °C	180	30
13	Fe₃O₄/f-MWCNT-CS	10	Solvent-free	110 °C	180	10
14	Fe₃O₄/f-MWCNT	10	Solvent-free	110 °C	180	10
15	Fe₃O₄	10	Solvent-free	110 °C	180	—