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. 2022 May 9;119(20):e2118430119. doi: 10.1073/pnas.2118430119

Fig. 5.

Fig. 5.

Local MSN inputs control striatal ChAT+ interneuron survival. (A) Schematic of experimental design. (B) Coronal sections through the striatum reveal the extent of the viral infection. Dashed lines indicate the boundary of the striatum. (C and D) Coronal sections through the dorsal striatum of vehicle- and CNO-treated Nkx2-1-Cre mice immunostained for PV (C) and ChAT (D). The schematic dot maps indicate the locations of striatal interneurons in each case. (E and F) Quantification of PV+ (E) and ChAT+ (F) interneuron density in the dorsal striatum of vehicle (n = 7)- and CNO-treated (n = 7 for PV and 8 for ChAT) Nkx2-1-Cre mice. PV+ interneurons: two-tailed unpaired Student’s t test, P = 0.97. ChAT+ interneurons: two-tailed unpaired Student’s t test, ***P < 0.001. Data in E and F are shown as box plots and the adjacent data points indicate the average cell density in each animal. (Scale bars, 500 µm.).